Integrins, Vascular Remodeling, and Hypertension
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چکیده
منابع مشابه
Integrins, vascular remodeling, and hypertension.
At the level of the resistance artery, hypertension also brings about a thickening of the vascular wall and inward encroachment on the lumen. This has been reported as being attributable to hypertrophy or hyperplasia of vascular smooth muscle cells (VSMCs), but studies have appeared suggesting that growth is not apparent in arteries at this level of the circulation.1 In addition, detailed struc...
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Remodeling of the vasculature is an active process of structural changes that involves alterations in cellular processes, including growth, apoptosis, migration, inflammation, and production of extracellular matrix proteins, resulting in an increase in the media:lumen ratio. Physiological remodeling is an adaptive response occurring in response to hemodynamic changes and ageing. However, when t...
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Integrins are heterodimeric cell surface receptors that mediate a cell's ability to perceive its environment, respond to changed in its environment, and alter its environment. When activated, these receptors form focal adhesions, which are areas of close attachment of the cells to extracellular matrix proteins in which colocalization of cytoskeletal proteins, intracellular signaling molecules, ...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2007
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000252753.63224.3b